The actors, who have known one another for a number of years, are reuniting to take a bike trip across Spain for Ride With Norman Reedus.
The 48-year-old, who is best known for his role as Daryl Dixon, will travel through Barcelona, Georgia and New York alongside a number of friends.
In the first instalment, fans of The Walking Dead star will see the motorcycle enthusiast meet with Jeffrey as well as a few thousand fans of the show.
Speaking about embarking on the trip with his cast mate, Norman explained in an exclusive clip: “Crossing the pond to take a ride with Negan himself, Jeffrey Dean Morgan, might be my most insane idea.”
The pair, who were also in the Spanish city for a press junket, revealed that they had been mobbed by fans with Jeffrey noting it was the “craziest thing I’ve ever seen”.
“Being new to The Walking Dead world – I’ve been gdoing this a long time, but I’ve never ever in my life seen anything like that,” he commented.
Norman agreed adding: “Yeah. Well, I mean, I’ve done seven years of it. I’ve never seen anything like that. That was bananas.”
“That was the craziest thing I’ve ever seen,” Jeffrey concluded.
Within the first ten minutes of the first episode of season two, fans will see the pair surrounded by adoring fans, with one woman asking to kiss Norman.
But while the pair may be best friends in Ride With Norman Reedus, in the zombie series it is a very different story and the most recent instalment saw one major star lose their life.
Fans of the show were devastated when King Ezekiel’s (played by Khary Payton) beloved tiger Shiva was killed by a horde of walkers during one of the goriest battles to date.
The King was left reeling from the death of his companion after he helped to save his life alongside Carol (Melissa McBride) and Jerry (Cooper Andrews), who had been injured.
The Walking Dead continues on AMC on Sunday and will follow a day later on FOX UK. Seasons one to seven are currently available to stream on NOW TV.
Ride With Norman Reedus premieres Wednesday at 9pm on AMC on BT TV.